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Marwan G. Fakih addresses the urgent need for new therapies in microsatellite-stable colorectal cancer and discusses how the treatment landscape is evolving with the introduction of agents like Botensilimab and Balstilimab, as well as the FOLFOX-3B regimen, presented at ASCO Gastrointestinal Cancers Symposium 2025. He evaluates the efficacy of these new agents, provides insights into their tolerability, and elaborates on the factors crucial for integrating these treatments into clinical practice, particularly in defining which patient populations will benefit most.
Jorge Castillo discusses the relative efficacy and safety of BTK inhibitors with or without BCL2 inhibitors in Waldenström’s macroglobulinemia (WM), highlights important prognostic molecular markers in untreated patients, and reveals new insights into the biology of the disease. He also explores novel therapeutic targets that may shape the future of WM treatment.