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Indication – Other cancers2024-06-04T09:58:03+01:00

Other cancers

间皮瘤和胸腺瘤治疗的逐步发展

January 12th, 2022|

这是一个重要的领域,但过去几乎没有取得任何进展。 在ESMO 2021上,Peters教授介绍了纳武单抗加伊匹单抗相比于化疗的随机化CheckMate-743试验的最新结果[1]。PD-L1阳性或非上皮样间皮瘤患者的总生存期获益显著,在总人群中也有OS获益。在瑞士,纳武单抗/伊匹单抗组合现已被批准用于治疗PD-L1阳性或非上皮样间皮瘤。

徐々に進展する中皮腫および胸腺腫の 治療管理法

January 6th, 2022|

切除できない悪性胸膜中皮腫への画期的な治療法の中では、どれが一番期待できるとお考えですか。  大変重要性の高い分野ですが、これまでに大きな進展は見られていません。そんな中、ランダム化比較試験のCheckMate-743試験でニボルマブとイピリムマブの併用療法を化学療法 と比較した最新成績を、Peters教授らがESMO 2021で発表しています。

Established and novel chemo-free combinations in immuno-oncology

December 11th, 2021|

Immunotherapy was the major breakthrough in the treatment of lung cancer in the past years. The PD-1 inhibitor pembrolizumab is approved for the treatment of various tumor entities including advanced or metastatic non-small cell lung cancer (a/mNSCLC). Lenvatinib, a multikinase inhibitor and antineoplastic agent that is so far approved for certain solid tumors but not NSCLC, already showed promising antitumoral effects and a manageable safety profile when combined with pembrolizumab in a phase I/II trial.

Immune checkpoint blockade combined with chemotherapy in solid tumors

December 11th, 2021|

Non-small cell lung cancer (NSCLC) is a severe disease with poor outcomes since the majority of patients present with stage IV disease at diagnosis. Approved treatment options in the first-line setting of advanced NSCLC (aNSCLC) with wildtype EGFR/ALK include bevacizumab - a VEGF targeting monoclonal antibody - and PD-1/PD-L1 inhibitors in combination with chemotherapy.

Gradual progress in the management of mesothelioma and thymoma

September 21st, 2021|

This is an important field where little progress has been made in the past. At ESMO 2021, updated results of the randomized CheckMate-743 trial of nivolumab plus ipilimumab versus chemotherapy were presented by Prof. Peters. The overall survival benefit was pronounced in patients with PD-L1–positive or non-epithelioid mesotheliomas, although there was an OS benefit in the total population.

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