ESMO Lung Cancer 2022 – Marina Garassino
Marina Garassino comments on checkpoint inhibition in lung cancer patients with oncogenic drivers, highlights novel developing therapies in EGFR-mutant NSCLC patients with resistance to TKIs, summarizes the most relevant findings presented at ESMO 2022 in terms of the management of patients with previously untreated, metastatic non-squamous and squamous NSCLC without EGFR/ALK alterations as well as patients with extensive-stage small-cell lung cancer; and finally discusses how artificial intelligence can be used to predict the efficacy of immunotherapy in lung cancer patients.
Here is the full ESMO 2022 Lung Cancer report.
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The close association between air pollution and increased lung cancer risk has been known for decades, although causation remained unknown. Lung cancer in never smokers is characterized by a low mutational burden and the absence of a carcinogen-induced DNA mutation signature. In general, evidence against the classical mutation model explaining tumor growth as a result of DNA mutations has emerged, thus raising the need for an alternative model.
Updates on immunotherapy-based treatment of stage III/IV disease
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Targeted approaches in the first and later lines: KRASG12C, EGFR, HER2 & angiogenesis
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Treatment benefits and outcome determinants in (neo)adjuvant trials
The adjuvant use of the third-generation EGFR tyrosine kinase inhibitor (TKI) osimertinib is being explored in the phase III ADAURA study that includes almost 700 patients with completely resected stage IB, II, and IIIA, EGFR-mutant non-small-cell lung cancer (NSCLC), with or without adjuvant chemotherapy.
Preface – ESMO Lung Cancer 2022
At the ESMO Congress held in Paris, France, and virtually from 9th to 13th September 2022, practice-changing data and high-quality education attracted more than 29,300 participants from over 150 countries.