WCLC 2023 – Yasushi Goto

Yasushi Goto discusses the effects of delta-like ligand 3 (DLL3) expression status on clinical outcomes in treated patients with small-cell lung cancer, explains in which ways DLL3 can be used as a direct target for treatment and highlights the challenges and future perspectives regarding DLL3-directed therapies in patients with SCLC. Lastly, he shares his thoughts on the optimal first-line therapy for patients with pleural mesothelioma.

Here is the full WCLC 2023 report.

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Refining first-line regimens for extensive-stage small-cell lung cancer

Improving long-term survival remains an unmet need in the setting of extensive-stage small-cell lung cancer ­(ES-SCLC). This might be attributed at least in part to the complexity of the tumor microenvironment, which is characterized by immunosuppression, angiogenesis and vascularization.

Improved anti-EGFR strategies and other targeted innovations

In the first-line setting of EGFR-mutant advanced NSCLC, EGFR tyrosine kinase inhibitors (TKIs) such as the third-generation agent osimertinib have been established as the standard of care, although treatment is followed by disease progression in most patients. Data on the combined administration of EGFR TKIs with chemotherapy suggest enhanced efficacy.

Detection and treatment of early-stage lung cancer: recent insights

Given the high incidence and mortality rates of lung cancer in Taiwan and the ­established association between survival and disease stage at diagnosis, the ­Taiwanese national early detection program for lung cancer was launched in July 2022 with the aim of increasing the proportion of tumors identified at an early stage using low-dose CT (LDCT).

Preface – WCLC 2023

The International Association for the Study of Lung Cancer (IASLC) 2023 World Conference on Lung Cancer (WCLC) was held in Singapore and virtually from 9th to 12th September. This prestigious event served as a global gathering point uniting over 6,000 renowned international scientists, researchers, and devoted patient advocates.