Anti-angiogenic combinations excel in later lines

The ongoing, prospective, non-interventional VARGADO study is assessing the angiokinase inhibitor nintedanib plus docetaxel in patients with advanced adenocarcinoma of the lung after first-line chemotherapy in routine clinical practice. VARGADO is conducted at approximately 100 sites across Germany and includes 3 cohorts.

Extensive-disease small-cell tumors: signals of activity

Most of the patients with small-cell lung cancer (SCLC) are diagnosed in the extensive-disease stage (ED-SCLC). They generally respond well to first-line platinum-based chemotherapy; however, responses are not durable, and prognosis is poor. In the second line and beyond, the NCCN guidelines recommend patient inclusion in a clinical trial, systemic therapy depending on the patient performance status and the duration of the relapse-free interval, or palliative symptom management.

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