WCLC 2022 – Helmut Popper

Helmut Popper talks about the characteristics of the recently defined molecular subtypes of small-cell lung cancer (SCLC), outlines if this subtyping is suitable for therapeutic decision-making and gives an overview about potential new therapeutic targets in the field of SCLC.

Here is the full WCLC 2022 report.

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Immune-based strategies are raising hope in small-cell tumors

Especially after frontline chemoimmunotherapy, treatment options are limited in patients with small-cell lung cancer (SCLC). Notch ligand delta-like ligand 3 (DLL3) represents a potential therapeutic target as it is aberrantly expressed on the surface of SCLC cells. By binding both DLL3 and CD3, the bispecific T cell engager (BiTE©) tarlatamab induces T-cell–mediated tumor lysis.

Stage I-III disease: surgical and systemic options

Lobar resection has been the surgical standard of care for cT1 N0 non–small-cell lung cancer (NSCLC) for decades, while sublobar resection (SLR) was reserved for a subset of patients with marginal pulmonary reserve. However, the recently published JCOG0802/WJOG4607L study showed that in fit patients with cT1a N0 tumors sized ≤ 2 cm, segmentectomy was not inferior to lobectomy regarding overall survival (OS).

Promising findings across oncogenic targets

The EGFR-MET bispecific antibody amivantamab is being assessed in combination with the third-generation EGFR tyrosine kinase inhibitor lazertinib in the multicohort CHRYSALIS-2 trial in patients with EGFR-mutant non–small-cell lung cancer (NSCLC). Results from the cohort receiving amivantamab/lazertinib in addition to carbo­platin/pemetrexed (n = 20) were presented at WCLC 2022 by Marmarelis et al.

Preface – WCLC 2022

The International Association for the Study of Lung Cancer (IASLC) 2022 World Conference of Lung Cancer (WCLC) was held in Vienna, Austria, and virtually from 6th to 9th August and saw leading scientists, researchers and patient advocates from around the world gather again to discuss the most exciting updates in the field of lung cancer and thoracic oncology with key updates summarized in 380 invited lectures, 60 oral and 84 mini oral ­presentations, as well as almost 1,000 posters and ePosters.