Neoadjuvant chemotherapy (CT), which has been the standard-of-care for resectable NSCLC, resulted only in modest survival benefits of approximately 5 %. However, CT combined with neoadjuvant immunotherapy is a promising strategy in improving survival outcomes of patients with resectable NSCLC. Hence, several small single-arm phase II studies are ongoing in this setting, all including patients with stage III disease.
Interleukin-8 (IL-8), also known as chemokine (C-X-C motif) ligand 8, is a pro-inflammatory chemokine that exerts direct pro-tumorigenic effects primarily by recruiting immunosuppressive cells into the tumor microenvironment such as neutrophils and myeloid-derived suppressor cells. IL-8 has also been shown to promote cancer progression and resistance to therapy, by inducing angiogenesis, epithelial-mesenchymal transition (EMT), and cancer stem cell (CSC) self-renewal.
Small-cell lung cancer (SCLC) accounts for about 15 % of all diagnosed cases of lung cancer and is characterized by a high proliferative rate, an early development of widespread metastases and a poor prognosis. The five-year survival rate is less than 7 %. More than two-thirds of patients with this highly aggressive neuroendocrine tumor are diagnosed with advanced or extensive-stage disease (ES-SCLC).
The ESMO Immuno-Oncology Congress took place in Geneva, Switzerland, and virtually from 7th to 9th December 2022. In total, more than 2,000 participants from more than 100 countries attended one of the 31 sessions featuring over 249 presented abstracts, 6 late breaking abstracts, 6 proffered paper, 14 mini orals and 229 posters.
ESMO IO 2021 - David McDermott David McDermott de ...
ESMO IO 2021 - Mark G. Kris Mark G. Kris outlines ...
Immunotherapy was the major breakthrough in the treatment of lung cancer in the past years. The PD-1 inhibitor pembrolizumab is approved for the treatment of various tumor entities including advanced or metastatic non-small cell lung cancer (a/mNSCLC). Lenvatinib, a multikinase inhibitor and antineoplastic agent that is so far approved for certain solid tumors but not NSCLC, already showed promising antitumoral effects and a manageable safety profile when combined with pembrolizumab in a phase I/II trial.
Non-small cell lung cancer (NSCLC) is a severe disease with poor outcomes since the majority of patients present with stage IV disease at diagnosis. Approved treatment options in the first-line setting of advanced NSCLC (aNSCLC) with wildtype EGFR/ALK include bevacizumab - a VEGF targeting monoclonal antibody - and PD-1/PD-L1 inhibitors in combination with chemotherapy.
The ESMO Immuno-Oncology Congress 2021 took place as a hybrid event either in Geneva or online from 8th to 11th December 2021. Compared with the annual ESMO scientific congress, this meeting focused exclusively on the most exciting new data in the promising field of immuno-oncology. In total, 1,124 participants from 67 countries attended one of the 31 on-demand sessions featuring over 193 abstracts, 178 e-posters, 146 presentations and 20 educational sessions.
