ASH 2020 – virtual
Lecture Board: Paul Barr, MD; Chan Cheah, MBBS; Paolo Ghia, MD, PhD; Preetesh Jain, MD, PhD; Stephen Opat, MD; Kerry Rogers, MD; Alessandra Tedeschi, MD
Medical Writer: Dr. Judith Moser
Preface – ASH 2020
Preface – ASH 2020 Heinz Ludwig, MD, Director of the Wilhelminen Cancer Research Institute, Department of Medicine I, Center for Oncology, Hematology and Palliative Care, Wilhelminen Hospital, Vienna, Austria Dear Colleagues, The ASH Annual Meeting and Exposition is the premier event for presentation of novel data on malignant and non-malignant hematologic diseases, attracting up to 30,000 specialists from all over the world.
What is new in Waldenström’s macroglobulinemia?
What is new in Waldenström’s macroglobulinemia? Constitutive activation of the Bruton’s tyrosine kinase (BTK) pathway has been shown to induce malignant cell survival in patients with Waldenström’s macroglobulinemia (WM) [1, 2].
Management of CLL patients: BTK inhibition and beyond
Management of CLL patients: BTK inhibition and beyond BTK inhibitors, the Bcl-2 inhibitor venetoclax and anti-CD20 antibodies such as obinutuzumab have dramatically changed the therapeutic landscape of chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL).
Insights from early clinical trials on targeted treatment in B-cell malignancies
Insights from early clinical trials on targeted treatment in B-cell malignancies DTRM-555: fixed-dose combination Richter’s transformation (RT), which describes transformation of CLL/SLL to diffuse large B-cell lymphoma (DLBCL) or Hodgkin lymphoma, is a rare event occurring in approximately 5–7 % of CLL cases [1].
Approaching marginal zone lymphoma from various angles
Approaching marginal zone lymphoma from various angles Approximately 10 % of Non-Hodgkin lymphomas are classified as marginal zone lymphoma (MZL) [1].
Advancing treatment in patients with mantle cell lymphoma
Advancing treatment in patients with mantle cell lymphoma Update on acalabrutinib monotherapy High relapse rates after standard-of-care regimens in the frontline setting are typical of mantle cell lymphoma (MCL), which is an aggressive, rare, B-cell Non-Hodgkin lymphoma [1-4].
Finding the way among a multitude of targets and regimens
Finding the way among a multitude of targets and regimens Stephen Opat, MD, School of Clinical Sciences at Monash Health, Monash University, Melbourne, Australia Under which conditions might patients with chronic lymphocytic leukemia achieve long-term treatment-free remission?
PD-1 inhibition and (Non-)Hodgkin lymphoma: promising outcomes in an emerging field
PD-1 inhibition and (Non-)Hodgkin lymphoma: promising outcomes in an emerging field Nivolumab plus BV for MGZL treatment Mediastinal gray zone lymphoma (MGZL) is an extremely rare type of Non-Hodgkin lymphoma with a predominance in young men [1].
Bone marrow microenvironment: culprit and target
Bone marrow microenvironment: culprit and target Jorge J. Castillo, MD, Dana-Farber Cancer Institute, Boston, USA Apart from factors such as genetic events that contribute to the malignant transformation in Waldenström’s macroglobulinemia (WM), the bone marrow microenvironment has been identified as a crucial player in WM disease progression [1].
序言
序言 Heinz Ludwig, MD 威廉明娜癌症研究所主任 肿瘤学、血液学和姑息护理中心医药I部 奥地利维也纳威廉明娜医院 亲爱的同事们， ASH年会暨展览会是介绍恶性及非恶性血液病相关新数据的重要活动，吸引了来自全球多达30,000名专家。
华氏巨球蛋白血症领域有何新进展？
华氏巨球蛋白血症领域有何新进展？ 研究表明，布鲁顿酪氨酸激酶（BTK）途径的组成性激活可诱导华氏巨球蛋白血症（WM）患者的恶性细胞存活[1,2]。该疾病是基于分泌IgM的克隆性淋巴浆细胞在骨髓和髓外部位的积累[3]。MYD88L265P突变（> 90 %的病例）和CXCR4WHIM样突变（大约27 %的病例）已被确定为WM的病理学标志 [4-6]。
CLL患者管理：BTK抑制及其他
CLL患者管理：BTK抑制及其他 BTK抑制剂、Bcl-2抑制剂维奈托克（venetoclax）和诸如阿托珠单抗（obinutuzumab）等抗CD20抗体已大大改变了慢性淋巴细胞性白血病（CLL）/小淋巴细胞性淋巴瘤（SLL）的治疗前景。依鲁替尼，作为BTK抑制剂类的第一代代表，是主要治疗手段，但其明显的缺点导致引入了第二代药物。
来自B细胞恶性肿瘤靶向治疗早期临床试验的见解
来自B细胞恶性肿瘤靶向治疗早期临床试验的见解 DTRM-555： 固定剂量的组合 Richter转化（RT）描述了CLL/SLL向弥漫性大B细胞淋巴瘤（DLBCL）或霍奇金淋巴瘤的转化，是一种发生在大约5-7 %的CLL病例中的罕见事件[1]。
从多种角度尝试治疗边缘区淋巴瘤
从多种角度尝试治疗边缘区淋巴瘤 约10 %的非霍奇金淋巴瘤被分类为边缘区淋巴瘤（MZL）[1]。这是一种异质性恶性肿瘤，由次级淋巴滤泡边缘区域的记忆B细胞引起，具有三种主要的亚型（即结外、结内、脾脏）[2,3]。
套细胞淋巴瘤患者中的先进疗法
套细胞淋巴瘤患者中的先进疗法 阿卡替尼单药疗法的最新进展 套细胞淋巴瘤（MCL）的典型特征在于一线标准护理方案后的高复发率，它是一种侵袭性、罕见的B细胞非霍奇金淋巴瘤[1-4]。基于单组、开放标签、多中心、II期ACE-LY-004研究，第二代高选择性BTK抑制剂阿卡替尼已在美国被批准用于治疗经过≥1种先前疗法的MCL患者[5] 。
在众多靶标和方案中寻找出路
在众多靶标和方案中寻找出路 专访：Stephen Opat, MD, 澳大利亚墨尔本莫纳什大学莫纳什健康临床科学学院 Stephen Opat, MD, 澳大利亚墨尔本莫纳什大学 莫纳什健康临床科学学院 慢性淋巴细胞性白血病患者在哪种情况下可以实现长期无治疗的缓解？ 在这里我想强调两个因素。第一个因素涉及有利的疾病生物学。免疫球蛋白基因突变或者缺乏TP53突变或17p缺失的患者更有可能获得无治疗的缓解。
PD-1抑制和（非）霍奇金淋巴瘤：在新兴领域的结果可期
PD-1抑制和（非）霍奇金淋巴瘤：在新兴领域的结果可期 纳武单抗（Nivolumab）加BV用于MGZL治疗 纵隔灰区淋巴瘤（MGZL）是一种非常罕见的非霍奇金淋巴瘤，主要出现在年轻男性中[1]。该病表现出在结节性硬化经典霍奇金淋巴瘤（cHL）与原发性纵隔B细胞淋巴瘤（PMBL）之间的过渡特征[2, 3]。
骨髓微环境：元凶和靶标
骨髓微环境：元凶和靶标 Jorge J. Castillo, MD 美国波士顿 达纳-法伯癌症研究所 除了诸如引起华氏巨球蛋白血症（WM）恶性转化的遗传事件等因素外，骨髓微环境还被认为是WM疾病进展的关键因素[1]。同样，它对于多发性骨髓瘤（MM）的出现和进展似乎必不可少，并且是MM患者难以治愈且不可避免会复发的重要原因[2]。大约在15年前，在骨髓微环境的背景下对恶性细胞生长的描述就已成为研究的重点，因为这可能实现针对MM和WM设计更有效的治疗策略。
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Steven P. Treon explains about innovative approaches in the treatment of Waldenström’s macroglobulinemia, future aspects and the successful use of BTK inhibition within niche groups of patients with WM, and potential benefits of BTK inhibitors regarding COVID-19 complications.
Jorge Castillo relates to recent developments with respect to follicular lymphoma, multiple myeloma and Waldenström’s macroglobulinemia, current insights into CAR-T cell therapy in the setting of multiple myeloma, and the future of anti-CD38 antibody treatment in patients with Waldenström’s macroglobulinemia.
Alessandra Tedeschi summarizes the results from the MAGNOLIA and iNNOVATE trials, relates to recent advances in the management of marginal zone lymphoma and discusses the effect of the introduction of BTK inhibition on the prognosis of patients with Waldenström’s macroglobulinemia.
Stephen Opat discusses the requirements for treatment-free long-term remission in the setting of CLL and talks about the future of BTK inhibitors and promising combinations in B-cell malignancies in general, as well as the strengths and limitations of immune checkpoint inhibitors.
