Kohei Shitara talks about new promising agents in the treatment of advanced HER2-positive gastric/gastroesophageal junction adenocarcinoma and how existing drugs can blend into these new regimens. He overviews the current state of prognostic and predictive biomarkers in gastric cancer and gives an outlook on new biomarkers that are on the rise to guide therapy while finally summarizing his personal medical and scientific highlights at this year’s ASCO meeting.

Anna Spreafico depicts her personal highlights regarding immunotherapy plus chemotherapy or intensity-modulated radiotherapy for people with locally advanced nasopharyngeal cancer (NPC) at this year’s ASCO meeting, discusses if longitudinal plasma EBV DNA monitoring should be incorporated into the guidance of personalized disease management and future clinical trials, highlights the most promising agents explored in the 1L treatment of recurrent/metastatic NPC and overviews how the prognosis of those patients will evolve in the years to come.

Julien Edeline highlights which clinical trials examining combination approaches are anticipated to expand the treatment armamentarium for treatment-naïve patients with unresectable HCC and which new agents are promising in the second- and third-line treatment of advanced HCC. He gives an outlook on how the prognosis of patients with advanced HCC will evolve in the years to come while focusing on the quality of life in HCC as well as the impact of systemic treatment on it.

Ian Chau summarizes the notable efficacy and safety data obtained with nivolumab plus chemotherapy or ipilimumab versus chemo as 1L treatment for advanced ESCC in the CheckMate 648 trial and explains the role of EGFR inhibitors in the treatment of ESCC, especially in combination with radiation. He focuses on the treatment paradigm in advanced/metastatic ESCC and how it might change in the near future while also explaining the barriers to implementing precision oncology in the setting of ESCC.